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Diamond-Based Nanoscale Quantum Relaxometry for Sensing Free Radical Production in Cells

Publications associées (81)

Robust gamma-aminobutyric acid and energy metabolism measurements by proton and phosphorus magnetic resonance spectroscopy and fingerprinting

Magnetic resonance spectroscopy (MRS) is the only technique that can detect endogenous metabolites directly and non-invasively in vivo. It allows to identify different metabolites and analyze the dynamic neurochemical processes in the brain, skeletal muscl ...

EPFL2023

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Higher magic angle spinning (MAS) frequencies than currently available are desirable to improve spectral resolution in NMR and EPR systems. While conventional strategies employ pneumatic spinning limited by fluid dynamics, this paper demonstrates the devel ...

Amsterdam2023

Influence of DNP Polarizing Agents on Biochemical Processes: TEMPOL in Transient Ischemic Stroke

Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell

Hyperpolarization of 13C by dissolution dynamic nuclear polarization (dDNP) boosts the sensitivity of magnetic resonance spectroscopy (MRS), making possible the monitoring in vivo and in real time of the biochemical reactions of exogenously infused 13C-lab ...

2023

Improvements in Resolution of 1H NMR of Solids

David Lyndon Emsley, Bruno Simões de Almeida

Magic angle spinning (MAS) in 1H NMR has allowed progress from featureless spectra in static samples to linewidths of a few hundreds of Hertz for powdered solids at the fastest spinning rates available today (100-150 kHz). While this is a remarkable improv ...

SWISS CHEMICAL SOC2023

Mechanistic studies of DNP and applications of hyperpolarized probes to study renal physiology and metabolism

Alice Radaelli

Dissolution dynamic nuclear polarization (dDNP) is a powerful technique that enhances the magnetic resonance signal of nuclear spins by several orders of magnitude. DNP relies on the principle of cross-relaxation by electron spins driven out of equilibrium ...

EPFL2021

Advanced single voxel 1 H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

Lijing Xin

Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite c ...

2020

B(0)shimming for in vivo magnetic resonance spectroscopy: Experts' consensus recommendations

Rolf Gruetter, Cristina Ramona Cudalbu

Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) allow the chemical analysis of physiological processes in vivo and provide powerful tools in the life sciences and for clinical diagnostics. Excellent homogeneity of the static B(0)magn ...

2020

Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: Background and experts' consensus recommendations

Cristina Ramona Cudalbu, Bernard Lanz

With a 40-year history of use for in vivo studies, the terminology used to describe the methodology and results of magnetic resonance spectroscopy (MRS) has grown substantially and is not consistent in many aspects. Given the platform offered by this speci ...

WILEY2020

UV-Irradiated 2-Keto-(1-C-13)Isocaproic Acid for High-Performance C-13 Hyperpolarized MR

Andrea Capozzi, Arthur César Pinon

Enhancing the sensitivity of magnetic resonance spectroscopy/imaging (MRS/MRI) by dissolution dynamic nuclear polarization (dDNP) has expanded the scope of MRS applications to new fields of research. Most importantly, it has paved the way toward noninvasiv ...

AMER CHEMICAL SOC2020

MATHICSE Technical Report : An elliptic local problem with exponential decay of the resonance error for numerical homogenization

Assyr Abdulle, Doghonay Arjmand, Edoardo Paganoni

multiscale methods homogenization resonance error ...

MATHICSE2020

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