Publication
Grape polyphenols decrease circulating branched chain amino acids in overfed adults
Publications associées (34)
Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet
João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares, Blanca Lizarbe Serra
Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to ...
2019Weight Loss Directly Influences Intermediate-Term Remission of Diabetes Mellitus After Bariatric Surgery: A Retrospective Case-Control Study
Purpose Roux en Y gastric bypass surgery (RYGB) is an effective therapy for patients with severe obesity. It induces both significant weight loss and rapid improvements of metabolic complications. This study was undertaken to better define the direct role ...
2019The role of the transcriptional regulator BCL6 in adipose tissue development and remodeling
The adipose tissue is increasingly recognized for the important role it plays in various diseases and pathological conditions, such as obesity, diabetes, cardiovascular diseases, osteoporosis, cancer, and aging. Despite its long-held reputation for being a ...
EPFL2019Peptides stimulating synthesis of extracellular matrix used in anti-ageing cosmetics: Are they clinically tested? A systematic review of the literature
Florentino Luciano Caetano Dos Santos
Peptides stimulating synthesis of extracellular matrix are now commonly used in the production of anti-ageing cosmetics. However, much uncertainty still exists about the methodology of their clinical assessment. The aim of the study was to review the liter ...
WILEY2019Discovery and validation of temporal patterns involved in human brain ketometabolism in cerebral microdialysis fluids of traumatic brain injury patients
Sarah Catherine Sonnay, Anirikh Chakrabarti, Mojgan Masoodi, Nicolas Christinat
Background: Traumatic brain injury (TBI) is recognized as a metabolic disease, characterized by acute cerebral glucose hypo-metabolism. Adaptive metabolic responses to TBI involve the utilization of alternative energy substrates, such as ketone bodies. Cer ...
ELSEVIER SCIENCE BV2019Effect heterogeneity and variable selection for standardizing causal effects to a target population
Mats Julius Stensrud, Anders Huitfeldt
The participants in randomized trials and other studies used for causal inference are often not representative of the populations seen by clinical decision-makers. To account for differences between populations, researchers may consider standardizing resul ...
2019Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS
Rolf Gruetter, Lijing Xin, Özlem Ipek, Mojgan Masoodi, Nicolas Christinat, Maya Shevlyakova
Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brains remain unclear. Here we report that ketones can increase ...
2018N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial
Rolf Gruetter, Lijing Xin, Alessandra Griffa, Patric Hagmann, Kim Do
Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown that N-acetylcysteine (NAC), an antioxidant and glutathione (GSH) precursor almost devoid of side e ...
2018Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice
Rolf Gruetter, Hongxia Lei, Jonathan Paz Montoya, Marc Moniatte, Ana Francisca Leal Silva Soares
Ectopic lipid accumulation in the liver is implicated in metabolic disease in an age- and sex-dependent manner. The role of hepatic lipids has been well established within the scope of metabolic insults in mice, but has been insufficiently characterized un ...
Wiley-Blackwell2017Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate
Arnaud Comment, Josefina Adriana Maria Bastiaansen
Cardiac dysfunction is often associated with a shift in substrate preference for ATP production. Hyperpolarized (HP) (13)C magnetic resonance spectroscopy (MRS) has the unique ability to detect real-time metabolic changes in vivo due to its high sensitivit ...
2016