Publication
Notch1 signaling is limited in healthy mature kidneys in vivo
Publications associées (32)
Towards Uncovering the Mechanisms of Electrophile Sensing and Signaling
Native reactive electrophile species (RES) such as 4-hydroxynonenal (HNE) act as cellular signals through covalent modification of kinetically-privileged electrophile sensor proteins. Research efforts in the field focus mainly on identifying these sensor p ...
EPFL2023Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation
Yimon Aye, Pierre Alexander Miranda Herrera
ABSTRACT: Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are under active debate. However, in our opinion, it is becoming increasingly likely that electrophile ...
AMER CHEMICAL SOC2022Premature Vertebral Mineralization in hmx1-Mutant Zebrafish
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development, and mutations in HMX1 are linked to an ocular defect termed oculoauricular syndrome of Schorderet-Munier-Franceschetti (OAS) (MIM #612109). Recently, additional altered oro ...
2022Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies
Mechanistic modeling of signaling pathways mediating patient-specific response to therapy can help to unveil resistance mecha-nisms and improve therapeutic strategies. Yet, creating suchmodels for patients, in particular for solid malignancies, is chal-len ...
2020Multi-color Molecular Visualization of Signaling Proteins Reveals How C-Terminal Src Kinase Nanoclusters Regulate T Cell Receptor Activation
Elucidating the mechanisms that controlled T cell activation requires visualization of the spatial organization of multiple proteins on the submicron scale. Here, we use stoichiometrically accurate, multiplexed, single-molecule super-resolution microscopy ...
CELL PRESS2020Modeling metabolic and signaling pathways in cancer cells
Cancer is a leading cause of death in the world, and the mechanisms that underlie this disease are still not completely understood. As cancer develops and progresses, cells undergo a diversity of mutations that sustain their rapid proliferation and the eva ...
EPFL2020Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells
Felix Naef, David Michael Suter, Torgil Elias Friman, Onur Tidin
The transduction of extracellular signals through signaling pathways that culminate in a transcriptional response is central to many biological processes. However, quantitative relationships between activities of signaling pathway components and transcript ...
2019Proteome-Wide Effect of 17-beta-Estradiol and Lipoxin A(4) in an Endometriotic Epithelial Cell Line
Endometriosis affects approximately 10% of women of reproductive age. This chronic, gynecological inflammatory disease results in a decreased quality of life for patients, with the main symptoms including chronic pelvic pain and infertility. The steroid ho ...
Frontiers Media Sa2016Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer
The Notch signaling pathway is a key regulator of cell fate decisions in embryonic development and in adult tissue homeostasis. Mounting evidence suggests that Notch signaling is frequently deregulated in human neoplasms, where depending upon the cellular ...
EPFL2016Perturbed rhythmic activation of signaling pathways in mice deficient for Sterol Carrier Protein 2-dependent diurnal lipid transport and metabolism
Cédric Gobet, Sylviane Métairon, Frédéric Bruno Martin Gachon, Mojgan Masoodi, Celine Jouffe
Through evolution, most of the living species have acquired a time keeping system to anticipate daily changes caused by the rotation of the Earth. In all of the systems this pacemaker is based on a molecular transcriptional/translational negative feedback ...
Nature Publishing Group2016