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SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

Publications associées (33)

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Xiaoxu Li, Jun Yong Kim, Maroun Bou Sleiman

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

NATURE PORTFOLIO2023

Interindividual variability of human thermoregulation: Toward personalized ergonomics of the indoor thermal environment

Dolaana Khovalyg

Objective The study was undertaken to show the magnitude of interindividual differences in energy expenditure (i.e., heat production) under normal living conditions with the aim of providing physiological evidence to support the advancement of a personaliz ...

WILEY2022

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

Johan Auwerx

MicroRNAs (miRNAs) have been implicated in oxidative metabolism and brown/beige adipocyte identity. Here, we tested whether widespread changes in miRNA expression promoted by treatment with the small-molecule enoxacin cause browning and prevent obesity. En ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Co-designing electronics with microfluidics for more sustainable cooling

Elison de Nazareth Matioli, Remco Franciscus Peter van Erp, Luca Nela, Georgios Kampitsis, Reza Soleiman Zadeh Ardebili

Thermal management is one of the main challenges for the future of electronics1,2,3,4,5. With the ever-increasing rate of data generation and communication, as well as the constant push to reduce the size and costs of industrial converter systems, the powe ...

2020

Optimal retrofit and investment planning methodologies for improving industrial energy and resource efficiency

Hür Ebuzer Bütün

A major shift in energy systems has started due to drastic changes in climate and air quality, depleting resources, as well as rising social awareness to all these changes. As a result international protocols, such as the Paris agreement, are signed settin ...

EPFL2020

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

Lilia Noriega Lopez, Laura Alejandra Velazquez Villegas

White adipose tissue (WAT) can differentiate into beige adipose tissue by the browning process. Some polyphenols, including isoflavones, particularly genistein, are suggested to increase the expression of browning markers. There is evidence that consumptio ...

ELSEVIER SCIENCE INC2019

A Holistic Methodology for Optimizing Industrial Resource Efficiency

François Maréchal, Adriano Viana Ensinas, Ivan Daniel Kantor, Maziar Kermani, Anna Sophia Wallerand, Julia Granacher

Efficient consumption of energy and material resources, including water, is the primary focus for process industries to reduce their environmental impact. The Conference of Parties in Paris (COP21) highlighted the prominent role of industrial energy effici ...

2019

Methodologies for simultaneous optimization of heat, mass, and power in industrial processes

Maziar Kermani

EPFL2018

Methodology for efficient use of thermal energy in the chemical and petrochemical industry

Elfie Marie Méchaussie

The current European energy regulation, aligned with the European Union energy strategy and targets for the next decade, requires large industrial companies to regularly assess their energy performance and implement energy efficiency improvement measures. ...

EPFL2018

beta-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb(-/-)mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we inv ...

Amer Soc Clinical Investigation Inc2017

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