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SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

Publications associées (33)

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The current regulatory framework in Europe regarding industrial energy consumption puts emphasis on regular energy assessments and increasing energy efficiency. Among the available strategies to identify energy savings opportunities, Total Site Analysis (T ...

2016

Thermal microsensors for in vitro and in vivo monitoring of chemical and biological processes

Rima Padovani

Metabolism is a highly coordinated biochemical cellular activity indispensable for sustaining life, and is often related to mitochondrial functioning. Innovative technological approaches allowing the study of the thermal signature of chemical and metabolic ...

EPFL2016

Key Energy and Technological Aspects of Three Innovative Concepts of District Energy Networks

François Maréchal, Daniel Favrat, Samuel Henchoz, Patrick Chatelan

Energy needs in urban areas are heterogeneous by their nature, spatial distribution and temperature level required. Three concepts of district energy networks that could provide the energy services efficiently to a city centre are compared. The focus is on ...

2016

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We report on in vivo temperature measurements performed in mice at two specific sites of interest in the animal body over a period of several hours. In particular, the aim of this work was to monitor mouse metabolism during cold exposure, and to record pos ...

Springer Verlag2015

This thesis investigates a set of advanced topics inspired from the heat integration and the pinch technology, all tied around the challenge of identifying energy savings in large-scale chemical industrial plants. In search for a general-purpose methodolog ...

EPFL2015

Vitamin D and energy homeostasis-of mice and men

Johan Auwerx, Kristina Schoonjans, Alessia Perino

The vitamin D endocrine system has many extraskeletal targets, including adipose tissue. 1,25-Dihydroxyvitamin D-3, the active form of vitamin D, not only increases adipogenesis and the expression of typical adipocyte genes but also decreases the expressio ...

Nature Publishing Group2014

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that causes death of motor neurons. ALS patients and mouse models of familial ALS display organismal level metabolic dysfunction, which includes increased energy expenditure despite ...

Oxford University Press2014

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin

The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...

Public Library of Science2013

Heat Management for Process Intensification of Fast Exothermic Reactions in Microstructured Reactors

Julien Haber

Nowadays, the production in fine chemical and pharmaceutical industry is mostly carried out in large scale batch reactors having typically dimensions of a few meters to satisfy the demand of the market. Even though this technology has been widely used and ...

EPFL2013

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Richardus Houtkooper, Hiroyasu Yamamoto

SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to ...

Elsevier2011