Motifs for making tricycles

Christian Heinis
2023
Article

Résumé

Tricyclic peptides have reduced conformational flexibility, making them well suited for ligand development. Researchers have now generated large combinatorial libraries of tricyclic peptides using a disulfide-directing motif. Screening these libraries discovered binders to challenging protein targets.

Source officielle

https://infoscience.epfl.ch/record/302664?ln=fr

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