Publication
SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase
Publications associées (36)
Rhythmic modulation of transcriptional burst frequency in circadian gene promoters
Isogenic cells sharing a common environment present a large degree of heterogeneity in gene expression, and stochasticity inherent to transcription substantially participates in this cell-to-cell variability. Notably, a majority of mammalian genes are tran ...
EPFL2017Eukaryotic transcription factor binding kinetics
Transcription represents a key regulatory step in gene expression and transcription factors (TFs) are the key molecular players of this process. TFs inhibit or promote the assembly of the transcriptional machinery by binding DNA and several co-factors. Whe ...
EPFL2016Phase specific transcriptional regulation of circadian clock and metabolism in mouse liver
The molecular clock has been conserved from cyanobacteria to mammals and is believed to align behavioral and biochemical processes with the diurnal cycle. This cellular mechanism has been an advantage to increase the fitness of organisms through the abilit ...
EPFL2016Total Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation
The natural product fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete of the genus Nocardiopsis. It displays inhibitory activity against TNF-α-induced activation of NFκB, an important transcription factor and a potential t ...
EPFL2016Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation
Nicolai Cramer, Christoph Heinz
Fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete and displays inhibitory activity against TNF-α-induced activation of NFκB, an important transcription factor and a potential target for the treatment of different cancers and ...
American Chemical Society2015Modeling of transcription mechanisms in mammals from kinetic measurements in single cells
In mammals, transcription was observed to occur predominantly in bursts, resulting from short and intense periods of gene transcription interspersed by longer silent periods. In order to elucidate the causes and the consequences of discontinuous transcript ...
EPFL2014Post-translational regulation enables robust p53 regulation
The tumor suppressor protein p53 plays important roles in DNA damage repair, cell cycle arrest and apoptosis. Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance towards fluctuatio ...
BioMed Central2013Kinetic Analysis of Transcriptional and Post-Transcriptional Processes During Circadian Cycles
Every morning the sun rises, flooding the earth with its light and heat and every night it disappears leaving the Earth in the darkness of the night. Organisms living on this planet have adapted to this solar rhythm and have spread their activities through ...
EPFL2013Virulence Regulator EspR of Mycobacterium tuberculosis Is a Nucleoid-Associated Protein
Stewart Cole, Jacques Rougemont, Florence Pojer, Claudia Sala, Ruben Hartkoorn, Swapna Uplekar, Jeffrey Chen, Benjamin Blasco
The principal virulence determinant of Mycobacterium tuberculosis (Mtb), the ESX-1 protein secretion system, is positively controlled at the transcriptional level by EspR. Depletion of EspR reportedly affects a small number of genes, both positively or neg ...
Public Library of Science2012Integrative Genomics Identifies the Corepressor SMRT as a Gatekeeper of Adipogenesis through the Transcription Factors C/EBPβ and KAISO
Bart Deplancke, Sebastian Martin Waszak, Sunil Kumar Raghav, Alina Isakova, Irina Krier
The molecular role of corepressors is poorly understood. Here, we studied the transcriptional function of the corepressor SMRT during terminal adipogenesis. Genome-wide DNA-binding profiling revealed that this corepressor is predominantly located in active ...
2012