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Primary data for "A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network"
Publications associées (64)
Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer
The Notch signaling pathway is a key regulator of cell fate decisions in embryonic development and in adult tissue homeostasis. Mounting evidence suggests that Notch signaling is frequently deregulated in human neoplasms, where depending upon the cellular ...
EPFL2016Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity
Matteo Dal Peraro, Deniz Aydin, Xiao Guo
The UbiB protein kinase-like (PKL) family is widespread, comprising one-quarter of microbial PKLs and five human homologs, yet its biochemical activities remain obscure. COQ8A (ADCK3) is a mammalian UbiB protein associated with ubiquinone (CoQ) biosynthesi ...
Cell Press2016A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa
Alexandre Louis André Persat, Joanne Netter Engel
Type IV pili (TFP) function as mechanosensors to trigger acute virulence programs in Pseudomonas aeruginosa. On surface contact, TFP retraction activates the Chp chemosensory system phosphorelay to upregulate 3', 5'-cyclic monophosphate (cAMP) production a ...
Wiley-Blackwell2016Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis
Olaia Maria Naveiras Torres-Quiroga, Nan Li
Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the developing embryo, yet the signals generated by hemodynamic forces that influence hematopoietic potential remain poorly defined. Here we show that fluid shear stress endows ...
2015Regulation of the mRNA silencing activity of Bicaudal-C
Cilia dysfunction is a common factor underlying left-right axis malformation and the pathogenesis of virtually all known renal cystic diseases. Mutations in the RNA-binding protein Bicaudal-C (Bicc1) provoke cystic kidneys reminiscent of polycystic kidney ...
EPFL2015The Drosophila MAPK p38c Regulates Oxidative Stress and Lipid Homeostasis in the Intestine
Bruno Lemaitre, Sveta Chakrabarti
The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various su ...
Public Library of Science2014Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release
Ralf Schneggenburger, Olexiy Kochubey, Özgür Genç
Transmitter release at synapses is regulated by preceding neuronal activity, which can give rise to short-term enhancement of release like post-tetanic potentiation (PTP). Diacylglycerol (DAG) and Protein-kinase C (PKC) signaling in the nerve terminal have ...
Elife Sciences Publications Ltd2014Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain
Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive impairment and neuropathology. Recent preclinical and epidemiological studies proposed statins as a possible therapeutic drug for Alzheimer's disease, but the exact ...
Shenyang Editorial Dept Neural Regeneration Res2013Optimal Design of Signaling Modules
One of the basic characteristics of every living system is the ability to respond to extracellular signals. This is carried out through a limited number of protein-based signaling networks, whose function is not based only on simple transmission of the rec ...
EPFL2012Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity
Gene transcription is essential for the establishment and the maintenance of long-term memory (LTM) and for long-lasting forms of synaptic plasticity. The molecular mechanisms that control gene transcription in neuronal cells are complex and recruit multip ...
2010