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Multi-species atlas resolves an axolotl limb development and regeneration paradox

Publications associées (32)

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HOX13-dependent chromatin accessibility underlies the transition towards the digit development program

Alexandre Gauthier Aurèle Mayran

Hox genes encode transcription factors (TFs) that establish morphological diversity in the developing embryo. The similar DNA-binding motifs of the various HOX TFs contrast with the wide-range of HOX-dependent genetic programs. The influence of the chromat ...

2020

Fryns type mesomelic dysplasia of the upper limbs caused by inverted duplications of the HOXD gene cluster

Denis Duboule

The HoxD cluster is critical for vertebrate limb development. Enhancers located in both the telomeric and centromeric gene deserts flanking the cluster regulate the transcription of HoxD genes. In rare patients, duplications, balanced translocations or inv ...

NATURE PUBLISHING GROUP2020

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Background: Global analyses of gene expression during development reveal specific transcription patterns associated with the emergence of various cell types, tissues, and organs. These heterogeneous patterns are instrumental to ensure the proper formation ...

BMC2018

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The mammalian HoxD cluster lies between two topologically associating domains (TADs) matching distinct enhancer-rich regulatory landscapes. During limb development, the telomeric TAD controls the early transcription of Hoxd genes in forearm cells, whereas ...

Cold Spring Harbor Laboratory Press2017

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

Denis Duboule, Guillaume Andrey, Dagmar Iber, Jing Liu

The large spectrum of limb morphologies reflects the wide evolutionary diversification of the basic pentadactyl pattern in tetrapods. In even-toed ungulates (artiodactyls, including cattle), limbs are adapted for running as a consequence of progressive red ...

Nature Publishing Group2014

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

Denis Duboule, Marion Leleu, Daniël Noordermeer

The evolution of tetrapod limbs from fish fins enabled the conquest of land by vertebrates and thus represents a key step in evolution. Despite the use of comparative gene expression analyses, critical aspects of this transformation remain controversial, i ...

Public Library Science2014

Regulatory Switches Underlie Hoxd Gene Activation in Tetrapod Limbs

Guillaume Andrey

Accurate spatio-temporal control of Hox cluster genes expression is critical for the proper organization of body structures during vertebrate embryogenesis. In the limbs, Hoxd genes are critical in setting up the proximodistal and anteroposterior axes. Sev ...

EPFL2013

CCCTC-binding factor (CTCF) is a nuclear zinc-finger protein that displays insulating activity in a variety of biological assays. For example, CTCF-binding sites have been suggested to isolate Hox gene clusters from neighboring transcriptional interference ...

Elsevier2010

Segmental Oscillators in Axial Motor Circuits of the Salamander: Distribution and Bursting Mechanisms

Auke Ijspeert

Ryczko D, Charrier V, Ijspeert A, Cabelguen JM. Segmental oscillators in axial motor circuits of the salamander: distribution and bursting mechanisms. J Neurophysiol 104: 2677-2692, 2010. First published September 1, 2010; doi:10.1152/jn.00479.2010. The rh ...

American Physiological Society2010

Embryogenesis depends on self-regulatory interactions between spatially separated signaling centers, but few of these are well understood. Limb development is regulated by epithelial-mesenchymal (e-m) feedback loops between sonic hedgehog (SHH) and fibrobl ...

2009