An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Michele De Palma
2024
Article

Résumé

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit anti-tumor immunity without the need for ex vivo antigen loading.

Source officielle

https://infoscience.epfl.ch/record/308712?ln=fr

À propos de ce résultat

Cette page est générée automatiquement et peut contenir des informations qui ne sont pas correctes, complètes, à jour ou pertinentes par rapport à votre recherche. Il en va de même pour toutes les autres pages de ce site. Veillez à vérifier les informations auprès des sources officielles de l'EPFL.

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Characterization of the gut-bone marrow axis through bile acid signaling

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

Characterization of the gut-bone marrow axis through bile acid signaling

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function