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Next-Generation Modeling of Cancer Using Organoids

Publications associées (34)

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Bioprinting the Cancer Microenvironment

Margaux Catherine Marie Duchamp

Cancer is intrinsically complex, comprising both heterogeneous cellular compositions and microenvironmental cues. During the various stages of cancer initiation, development, and metastasis, cell-cell interactions (involving vascular and immune cells besid ...

Amer Chemical Soc2016

Engineering opportunities in cancer immunotherapy

Melody Swartz, Laura Jeanbart

Immunotherapy has great potential to treat cancer and prevent future relapse by activating the immune system to recognize and kill cancer cells. A variety of strategies are continuing to evolve in the laboratory and in the clinic, including therapeutic non ...

Natl Acad Sciences2015

Molecular screening of cancer-derived exosomes by surface plasmon resonance spectroscopy

Horst Vogel, Niels Erik Lion, Davide Demurtas, Luigino Grasso, Michel Prudent, Romain Wyss, Ashwin Thampi, Lorenz Weidenauer

We report on a generic method to detect and iden- tify the molecular profile of exosomes either derived from cultured cell lines or isolated from biofluids. Exosomes are nanovesicles shed by cells into their microenvironment and carry the molecular identit ...

Springer Heidelberg2015

The long-term risk of malignancy associated with stem cell therapies is a significant concern in the clinical application of this exciting technology. We report a cancer-selective strategy to enhance the safety of stem cell therapies. Briefly, using a cell ...

Elsevier2014

The Mesenchymal Stem Cell (MSC) is a self-renewing multipotent progenitor originally found in the bone marrow. It has drawn strong interest from translational research because of the multipotency of MSCs, their immunosuppression, their intrinsic homing and ...

EPFL2014

Interactions between cancer stem cells and their niche govern metastatic colonization

Albert Santamaria Martinez, Ilaria Malanchi, Hans-Anton Lehr

Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successf ...

2012

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Douglas Hanahan

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constit ...

Elsevier2012

Cyclooxyganase-2 (COX-2), a rate-limiting enzyme in the prostaglandin synthesis pathway, is overexpressed in many cancers and contributes to cancer progression through tumor cell-autonomous and paracrine effects. Regular use of non-steroidal anti-inflammat ...

2012

Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses

Matthias Lütolf, Stefan Kobel

Background: Increasing evidence shows that the cancer microenvironment affects both tumorigenesis and the response of cancer to drug treatment. Therefore in vitro models that selectively reflect characteristics of the in vivo environment are greatly needed ...

Public Library of Science2012

Using the Swedish Familial Cancer Database, organized and studied by the Hemminki group since 1997, the hypotheses that breast, prostate and colorectal cancers were affected by familial risks in Sweden (1958-2008) are tested. The null hypotheses were rejec ...

2011