A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement

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Mechanical Reinforcement of Hydrogels through Physical Crosslinks and Double Network Granular Architecture

Alvaro Lino Boris Charlet

Throughout nature, organisms fabricate a myriad of materials to sustain their lifestyle. Many of the soft materials are composed of water-swollen networks of organic molecules, so-called hydrogels. They generally contribute to the mechanical integrity of t ...

EPFL2022

Overcorrected Implants for Total Shoulder Arthroplasty

Yasmine Boulanaache

Glenohumeral osteoarthritis is a degenerative shoulder joint disease, which causes the breakdown of articular cartilage and bone. People affected by this disease suffer from severe pain and eventually reduced mobility and poor life quality. This disease is ...

EPFL2021

Hybrid hydrogels for load-bearing implants

Céline Samira Wyss

Load-bearing tissues such as articular cartilage or meniscus are not infallible. They might fail due to trauma, over-solicitations, or diseases, which could subsequently alter the mobility of the patient. Repairing these damaged tissues in a minimally inva ...

EPFL2021

Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Dominique Pioletti, Christophe Moser, Mahmut Selman Sakar, Andreas Schmocker, Oriane Poupart, Lucio Feo Pancaldi-Giubbini

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

2021

Navigation Improves the Survival Rate of Mobile-Bearing Total Knee Arthroplasty by Severe Preoperative Coronal Deformity: A Propensity Matched Case-Control Comparative Study

Brigitte Jolles-Haeberli

The primary hypothesis of this study was that the survival rate over 10 years of total knee arthroplasties (TKAs) implanted with a navigation system was superior to that of TKAs implanted with a conventional technique. The secondary hypothesis was that the ...

GEORG THIEME VERLAG KG2021

Design and Development of Injectable, Tough and Intrinsically-Adhesive Hydrogels for Biomedical Applications

Peyman Karami

Despite the development of hydrogels with a wide range of mechanical properties, insufficient adhesion between these materials and biological surfaces limits their use in the biomedical applications. Most recent advancements in highly adhesive hydrogel sys ...

EPFL2021

Towards an in vitro cardiac model: 3D environment, co-culture, alignment, and mechanical stimulation impact on cell behavior

Fatemeh Navaee

Our aim is to develop a 3D model unit of cardiac muscle: an in-vitro analog of the trabeculae carneae found in vivo. As a base hydrogel matrix for cardiomyocyte culture in 3D, we develop a blend of decellularized extracellular matrix (dECM) and fibrin. Thi ...

EPFL2021

A Crevice Corrosion Model for Biomedical Trunnion Geometries and Surfaces Feature

Stefano Mischler, Anna Neus Igual Muñoz, Angela Bermudez Castañeda

Modular hip joint implants were introduced in arthroplasty medical procedures because they facilitate the tailoring of patients’ anatomy, the use of different materials in one single configuration, as well as medical revision. However, in certain cases, su ...

2021

Laser-induced liquid micro-jets for drug delivery

Jan Krizek

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

EPFL2021

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

Oriane Poupart

Intracranial aneurysm is a cerebrovascular disease characterized by an artery dilation in the brain. An aneurysm is prone to rupture, which causes a life-threatening subarachnoid hemorrhage. The major drawbacks of the current treatments, open surgical clip ...

EPFL2021

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Navigation Improves the Survival Rate of Mobile-Bearing Total Knee Arthroplasty by Severe Preoperative Coronal Deformity: A Propensity Matched Case-Control Comparative Study

Brigitte Jolles-Haeberli

GEORG THIEME VERLAG KG2021

Towards an in vitro cardiac model: 3D environment, co-culture, alignment, and mechanical stimulation impact on cell behavior

Fatemeh Navaee

EPFL2021