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Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

Publications associées (28)

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SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells

Loïc Dayon, Andreas Wiederkehr

Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...

COMPANY BIOLOGISTS LTD2023

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Pernille Yde Rainer

White adipose tissue (WAT) is a cellularly heterogeneous endocrine organ that not only serves as a reservoir for storing and releasing energy but also actively participates in metabolic homeostasis. Given the current rise in obesity and its associated como ...

EPFL2023

Cross-anatomical single-cell definition and characterization of human adipose progenitor niche

Radiana Ferrero

Adipose tissue is a key metabolic and highly-dynamic organ whose dysregulation may cause clinical conditions of concern such as obesity and lipodystrophy. Its function varies based on the anatomy, in fact, visceral adipose tissue expansion carries a greate ...

EPFL2023

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

Martinus Gijs, Raphaël Etienne Jean Trouillon, Martin Rainer Wohlwend

Microtubules serve as tracks for long-range intracellular trafficking of glucose transporter 4 (GLUT4), but the role of this process in skeletal muscle and insulin resistance is unclear. Here, we used fixed and live-cell imaging to study microtubule-based ...

eLIFE SCIENCES PUBL LTD2023

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Xiaoxu Li, Maroun Bou Sleiman, Jun Yong Kim

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

Nature Portfolio2023

Heat pumping and renewable energy integration for decarbonizing brewery industry and district heating

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos

The energy integration of brewery plants and urban agglomerations has many benefits in terms of rational energy use and reduced environmental impact, especially during scenarios of uncertain supply chain and volatile market prices. In fact, the diversifica ...

Elsevier2023

Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling

Felix Naef, Nicholas Edward Phillips

Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart rate variability (HRV) in ...

CELL PRESS2023

Renewable Energy Integration and Waste Heat Recovery for the Production of Sustainable Jet Fuel and Decarbonization of Industrial Heating Applications

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos, Réginald Germanier

The process synthesis and optimization methods used in this work include simulation of biomass gasification, hydrogen and synthetic natural gas production, and jet fuel production via a Fisher Tropsch unit. An energy integration approach, carried out by th ...

American Institute of Chemical Engineering2023

A systemic study for enhanced waste heat recovery and renewable energy integration towards decarbonizing the aluminium industry

François Maréchal, Daniel Alexander Florez Orrego, Réginald Germanier

The aluminium remelting industry relies on natural gas to transform recycled aluminium into aluminium feedstock, entailing significant atmospheric emissions. Hydric resources are also affected as they are used as sinks of waste heat from the casting proces ...

2023

Identification of typical district configurations: A two-step global sensitivity analysis framework

François Maréchal, Jonas Schnidrig, Cédric Terrier

The recent geopolitical conflicts in Europe highlighted the sensibility of the current energy system to the volatility of energy carrier prices. In the prospect of defining robust energy system configurations to ensure energy supply stability, it is necess ...

2023

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Uncovering personalized glucose responses and circadian rhythms from multiple wearable biosensors with Bayesian dynamical modeling

Felix Naef, Nicholas Edward Phillips

CELL PRESS2023

Renewable Energy Integration and Waste Heat Recovery for the Production of Sustainable Jet Fuel and Decarbonization of Industrial Heating Applications

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos, Réginald Germanier

American Institute of Chemical Engineering2023

A systemic study for enhanced waste heat recovery and renewable energy integration towards decarbonizing the aluminium industry

François Maréchal, Daniel Alexander Florez Orrego, Réginald Germanier

2023

Identification of typical district configurations: A two-step global sensitivity analysis framework

François Maréchal, Jonas Schnidrig, Cédric Terrier

2023

A single-cell-based characterization of mammalian adipose stem and progenitor cell heterogeneity and function

Pernille Yde Rainer

EPFL2023