Redefining the metabolic landscape through TGF-beta/Activin signaling in Drosophila melanogaster

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ROSMOSE: A Web-based Optimization Tool to Aid Decision-making for the Design and Operation of Industrial and Urban Energy Systems

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos, Cédric Terrier, Michel Lopez

Energy efficiency is crucial for the sustainable operation of all industrial and urban sectors. However, practicing engineers have seldom access to open-source tools that can readily evaluate and compare scenarios in terms of energy consumption, cost, and ...

2023

Decision support for the design of integrated biorefineries

Julia Granacher

A shift from fossil-based energy and products to more sustainable alternatives is essential to reduce greenhouse gas emissions and associated climate change impacts. Biomass represents a promising alternative for providing fuels and carbon-based products w ...

EPFL2023

Electrification and digitalization effects on sectoral energy demand and consumption: A prospective study towards 2050

François Maréchal, Fabian Heymann, Xiang Li

Energy transition is blurring the boundaries between the demand and supply sides with growing participation of prosumer resources. The intensifying pace of electrification and digitalization during the past decade tends to continue, leading to potential te ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Alternative energy supply approach for industrial complexes and district heating networks based on biomass integrated gasification

François Maréchal, Daniel Alexander Florez Orrego, Meire Ellen Gorete Ribeiro Domingos

In this work, a systematic approach combining different energy solutions and the time-varying energy demands is used to identify the operating conditions and arrangements for industrial complexes. A kraft pulp mill integrated to an urban district heating n ...

Universidad de Las Palmas de Gran Canaria2023

Optimal enzyme utilization suggests that concentrations and thermodynamics determine binding mechanisms and enzyme saturations

Vassily Hatzimanikatis, Daniel Robert Weilandt, Asli Sahin

One of the main challenges hampering the development of kinetic models is the lack of kinetic parameters for many enzymatic reactions. Here, the authors introduce a framework to explore the catalytically optimal operating conditions of any complex enzyme m ...

Nature Portfolio2023

An explainability framework for deep learning on chemical reactions exemplified by enzyme-catalysed reaction classification

Daniel Probst

Assigning or proposing a catalysing enzyme given a chemical or biochemical reaction is of great interest to life sciences and chemistry alike. The exploration and design of metabolic pathways and the challenge of finding more sustainable enzyme-catalysed a ...

2023

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

Maria Brbic, Sandy Lee

Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We c ...

American Association for the Advancement of Science2023

Hybridisation Scenarios of Solid Oxide Fuel Cells, Batteries, and Internal Combustion Engines for Waterborne Transportation

François Maréchal, Daniel Alexander Florez Orrego

The shipping industry was responsible for about 3% of global greenhouse gas (GHG) emissions in 2018. In this context, the International Maritime Organisation (IMO) has established stringent targets to reduce GHG emissions by at least 50% by 2050 compared t ...

Universidad de Las Palmas de Gran Canaria2023

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