Influence of TASP-V, a novel neuropeptide Y (NPY) Y-2 agonist, on nasal and bronchial responses evoked by histamine in anaesthetized pigs and in humans

1 In nine anaesthetized pigs we have studied the influence of intranasal or intrabronchial pretreatment with TASP-V, a neuropeptide Y (NPY) Y-2 agonist formed by the attachment of NPY 21-36 to a template-assembled synthetic peptide (TASP), on the functional responses to subsequent intranasal or intrabronchial histamine challenge. 2 In a parallel study, subjective and objective nasal airway resistance (NAR) increase following intranasal histamine challenge was evaluated in II healthy volunteers after TASP-V or placebo pretreatment. 3 In pigs, increase in sphenopalatine blood flow induced by histamine dihydrochloride nasal spray (0.25 mg kg(-1) in 3 mi of saline) was significantly reduced by 65% (P