Synthesis of biotinylated glycosulfopeptides by chemoselective ligation

Patricia Durieux
2001
Article

Résumé

Tyrosine sulfation and O-glycosylation are two post-translational modifications playing an essential role in modulation of biol. activity, protein folding and cellular communication. Here, a novel chem. approach for the synthesis of biotinylated glycosulfopeptides is described based on a combination of acid labile protecting groups, highly acid sensitive resins and two orthogonal chemoselective ligation reactions. [on SciFinder (R)]

Source officielle

https://infoscience.epfl.ch/record/76670?ln=fr

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Synthesis of biotinylated glycosulfopeptides by chemoselective ligation

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