Anisotropy of rotational diffusion, dipole-dipole cross-correlated NMR relaxation and angles between bond vectors in proteins
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Relaxation processes induced by the antisymmetric part of the chemical shift anisotropy tensor (henceforth called anti-CSA) are usually neglected in NMR relaxation studies. It is shown here that anti-CSA components contribute to longitudinal relaxation rat ...
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A polyubiquitin chain anchored to the substrate has been the hallmark of proteasomal recognition. However, the degradation signal appears to be more complex and to contain also a substrate's unstructured region. Recent reports have shown that the proteasom ...
A new strategy has been developed to measure cross-correlation rates with much enhanced accuracy. The method relies on the use of four complementary expts. Errors due to pulse miscalibration and to uncontrolled attenuation factors assocd. with relaxation a ...
Ubiquitylation provides a means of targeting substrate proteins for degradation by the proteasome. Novel findings in C. elegans (Hoppe et al., 2004, this issue of Cell) establish that two ubiquitin-ligases team up to multiubiquitylate the myosin chaperone ...
One-dimensional NOE expts. applicable to labeled macromols. are presented which allow the manipulation of specific spin diffusion pathways and thus unambiguously identify clandestine spins through which the direct NOE is mediated. A treatment of spin diffu ...
The Nedd8 ubiquitin-like protein modification pathway regulates cell-cycle progression. Our analysis of Nedd8 requirements during Caenorhabditis elegans embryogenesis indicates that the cytoskeleton is another target. Nedd8 conjugation negatively regulated ...
A review is given of the math. foundations of av. Liouvillian theory and examples are provided of av. Liouvillian expressions derived for sequences in NMR which possess temporal symmetry or antisymmetry. The utility of this approach is demonstrated in the ...
