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Interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha) markedly stimulate glucose utilization in primary cultures of mouse cortical astrocytes. The mechanism that gives rise to this effect, which takes place several hours after applicat ...
A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The n ...
American Association for the Advancement of Science2000
Time-integrated fluorescence expts. on native bacteriorhodopsin and on its non-isomerizing form bR5.12 are reported. The exptl. set-up was designed such as to observe emission exclusively from the excited state intermediate I-460. We obtain the first syste ...
The spectrally and temporally resolved fluorescence properties of native bacteriorhodopsin (bR) and bR reconstituted with a nonisomerizing analog of the retinal Schiff base (bR5.12) are examd. The first attempt to exptl. monitor the excited state relaxatio ...
Information on the temporal order, the kinetics, and the energetics of each of the reaction intermediates is required in order to fully elucidate the mechanism of catalytic interaction of G proteins with their receptors. Intrinsic monitors, such as light s ...
