Publications associées à Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis

Portable bioluminescence systems and methods for in vivo monitoring of molecular and metabolic events in animals

Aurélien Godinat, Elena Goun, Aleksey Yevtodiyenko

A system for monitoring biological processes in vivo is provided. The system comprises an implantable luciferase biosensor comprising luciferase in a biocompatible matrix and a caged luciferin probe. The caged luciferin probe can be administered to a livin ...

2018

Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhabitors

Stewart Cole, Jérémie Piton, Shi-Yan Caroline Foo

The flavoenzyme DprEl catalyses a crucial step in arabinan production for cell wall biosynthesis in Mycobacterium tuberculosis and is a highly vulnerable drug target. It was first discovered using benzothiazinones (BTZ): exquisitely potent bactericidal age ...

Elsevier Sci Ltd2017

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Stewart Cole, John McKinney, Neeraj Dhar, Claudia Sala, Ruben Hartkoorn, Anthony Vocat, Andréanne Lupien, Raphael Christopher Sommer

VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library. Sequencing of a VCC234718-resistant mutant identified a Y487C substitution in the inosine mo ...

Amer Chemical Soc2017

Synthesis of Adamantane Aminoethers with Antitubercular Potential

Stewart Cole, Anthony Vocat

Background: Intrigued by the fact that aminoadamantane derivatives, bearing the active 1,2-ethylenediamine moiety, are promising antitubercular agents, we report herein the synthesis and the antitubercular evaluation of N,N'-substituded-4,4'-[adamantane-2, ...

Bentham Science Publ Ltd2017

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

John McKinney, Neeraj Dhar, François Signorino-Gelo

Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of ison ...

Elsevier Science Bv2016

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis

Stewart Cole, Stefanie Boy-Röttger, Claudia Sala, Jérémie Piton, Gaëlle Séraphine Kolly, Joao Pedro De Almeida Neres, Jan Lars Rybniker, Benoit Lechartier, Shi-Yan Caroline Foo, Andréanne Lupien

Benzothiazinones (BTZs) are a class of compounds found to be extremely potent against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. The potency of BTZs is explained by their specificity for their target decaprenylphosphoryl-D ...

American Society for Microbiology2016

Mechanistic insight into mycobacterial MmpL protein function

Stewart Cole, Edina Rita Székely

Mycobacterial cell walls are complex structures containing a broad range of unusual lipids, glycolipids and other polymers, some of which act as immunomodulators or virulence determinants. Better understanding of the enzymes involved in export processes wo ...

Wiley-Blackwell2016

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis

Stewart Cole, Matteo Dal Peraro, Luciano Andres Abriata, Claudia Sala, Gaëlle Séraphine Kolly, Mahé Cécile Raccaud, Raju Mukherjee

Mycobacterium tuberculosis possesses a thick and highly hydrophobic cell wall principally composed of a mycolyl-arabinogalactan-peptidoglycan complex, which is critical for survival and virulence. DprE1 is a well-characterized component of decaprenyl-phosp ...

Amer Soc Microbiology2015

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Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

Portable bioluminescence systems and methods for in vivo monitoring of molecular and metabolic events in animals

Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhabitors

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Synthesis of Adamantane Aminoethers with Antitubercular Potential

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis

Mechanistic insight into mycobacterial MmpL protein function

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis

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Chattez avec Graph Search

More Medicines for Tuberculosis: Fuelling Drug Discovery against Mycobacterium tuberculosis

Structural studies of Mycobacterium tuberculosis DprE1 interacting with its inhabitors

Characterization of DprE1-Mediated Benzothiazinone Resistance in Mycobacterium tuberculosis

Mechanistic insight into mycobacterial MmpL protein function

Portable bioluminescence systems and methods for in vivo monitoring of molecular and metabolic events in animals

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Synthesis of Adamantane Aminoethers with Antitubercular Potential

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis