Mutants of human O6-alkylguanine-DNA alkyltransferase with improved properties
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The smaller isoform of the GABA-synthesizing enzyme, glutamic acid decarboxylase 65 (GAD65), is unusually susceptible to becoming a target of autoimmunity affecting its major sites of expression, GABA-ergic neurons and pancreatic β-cells. In contrast, a hi ...
The authors have prepd. beta-peptides I and II which contg. unlike-beta2,3-amino acids. The structures of beta-peptides I (prepd. in soln.) and II (prepd. on solid-phase) are reported. ...
Anti- V.cholerae monoclonal IgA antibodies have been produced using a hybridoma cell line (Zac3) grown in RPMI medium contg. 10% Fetal calf serum (FCS) and a completely defined protein- free medium. The latter has been optimized with respect to amino acid, ...
The puromycin-sensitive aminopeptidase (PSA) is thought to contribute to the degradation of enkephalins. Besides being the most abundant aminopeptidase in the brain, PSA is expressed in other organs as well. From a human fetal brain cDNA library, we have i ...
Comprehensive and cGMP suitable bioprocess monitoring is still a challenge in microbial fermn. and cell culture process development. This paper discusses the exploitation of in-situ mid-IR spectroscopy in combination with partial least-squares anal. to mon ...
The chloro-bridged complexes [CpMCl2]2 (Cp = C5Me5, M = Ir, Rh), [(p-cymene)RuCl2]2, [(C6Me6)RuCl2]2, and [(Et3P)PdCl2]2 react with SAMP by cleavage of the chloro bridges to give the corresponding monomeric h1-SAMP complexes. The x-ray structural detns. ...
Achieving practical biotechnol. processes for the prodn. of fine chems. requires optimization of metabolic fluxes. Attempts to alter the fluxes through a given pathway may be frustrated by compensatory changes in coupled pathways or by unexpected effects s ...
The formation of 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF) and 2(or 5)-ethyl-4-hydroxy-5(or 2)-methyl-3(2H)-furanone (EHMF) from pentose sugars was studied in Maillard model systems. The amts. generated at 90 DegC for 1 h were detd. by isotope diln. ass ...
The chloro-bridged complexes [CpMCl2]2 (Cp = C5Me5, M = Ir, Rh), [(p-cymene)RuCl2]2, [(C6Me6)RuCl2]2 and [(PEt3)PdCl2]2 react with SAMP by cleavage of the chloro bridges to give the corresponding monomeric h1-SAMP complexes. The x-ray structural detns. o ...
A chemically-defined protein-free medium (FMX-Turbodoma) has been improved for the production of monoclonal IgA antibodies by hybridoma cells, using a systematic method. Cell growth rate, IgA production, activity and molecular weight pattern have been used ...
