Prescriptions and ingredients for controlled carbon-carbon bond formation with organometallic reagents
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NiII complexes of the new pincer amidobis(amine) ligand are described. The Ni chloride complex catalyzes Kumada-Corriu-Tamao coupling of unactivated alkyl halides with alkyl Grignard reagents, as well as double C-C coupling of CH2Cl2 with alkyl Grignard re ...
A review. This review describes a concept aimed at rational and maximal structure proliferation. To this end, simple arom. or heterocyclic starting materials, often bulk chems., are converted into all regioisomerically possible polar organometallic interme ...
A new one-pot synthesis of sulfoxides is presented. It involves the bora-ene reaction of sulfur dioxide and prop-2-ene-1-boronic esters, giving mixed anhydrides of sulfinic and boric acids. The latter react chemoselectively at the sulfur center with Grigna ...
The present thesis work concerns the preparation and optionally site selective functionalization of five- and six-membered nitrogen heterocycles and the investigation of atropisomerism of α,o-bis(methoxymethyl)-1-phenylindole. Mono- and disubstituted 2-bro ...
(2,6-Dichlorophenyl)trimethyl- and triethylsilane exhibit untypical reactivity patterns toward strong bases: when treated at -100 °C with lithium 2,2,6,6-tetramethylpiperidide two, with sec- or tert-butyllithium even three organometallic intermediates are ...
Deprotonation-triggered heavy halogen migrations should become a favorite tool in arene synthesis if their occurrence and outcome could be made predictable. Particularly attractive, though extremely rare, are stop-and-go situations where a first intermedia ...
The use of organometallic reagents for functionalization of arenes and heterocycles has recently been renewed by our group. The use of bulky trialkylsilyl groups allows one to shield an acidic position by steric hindrance and the introduction of a chlorine ...
The metalation of 2,3-, 2,6-, 2,4- and 3,5-dichlorobenzotrifluorides can be readily effected with std. reagents such as lithium diisopropylamide, lithium 2,2,6,6-tetramethylpiperidide, and butyllithium at the chlorine-adjacent 4- and 3-positions and the ch ...
A review. Only the most important methods for the generation of organometallic reagents and intermediates are covered in this review. This holds for the reductive insertion of Li into org. halides, the permutational interconversion of org. halides with org ...
Among other things, the present thesis work aimed at a rational and maximal structure proliferation. Simple arenes or heteroarenes were functionalized regioselectively through organometallic intermediates, which then may be combined with any electrophile t ...
