o-Selective metalation and electrophilic substitution of benzylamine derivatives

1988
Article

Résumé

N-Pivaloylbenzylamines and derivs. [e.g., 2,4-R(MeO)C6H4CH2NHCOCMe3, I, R = H] undergo smooth ortho-metalation when treated with two equivs. of an organolithium reagent. Subsequent carboxylation or hydroxylation lead to a no. of products, e.g., I, R = CO2H, OH. [on SciFinder (R)]

Source officielle

https://infoscience.epfl.ch/record/81579?ln=fr

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