Post-training administration of a synthetic peptide ligand of the neural cell adhesion molecule, C3d, attenuates long-term expression of contextual fear conditioning
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Previous studies showed that exposure of rats to chronic restraint stress for 21 days enhances subsequent contextual fear conditioning. Since recent evidence suggest that this effect is not dependent on stress-induced neurodegenerative processes, but to el ...
Contextual fear conditioning under training conditions involving high stressor intensities has been proposed as an animal model for traumatic memories. The strength of memory for this task has been related to the intensity of the conditioning stressor and ...
This study investigates the functional role of corticosterone in memory formation for a passive avoidance task in the day-old chick. Whereas training chicks with a strong aversant results in an enduring memory, memory for a weak aversant which is only reta ...
Long-term memory formation for a passive avoidance task in day-old chicks, which requires a late phase of glycoprotein fucosylation (5-8 hr posttraining), is dependent on a corticosterone action in the brain. In addition, corticosterone enhances late-phase ...
We investigated the effects of piracetam, a nootropic, on learning and memory formation for a passive avoidance task in day-old chicks. To test for the possible cognitive-enhancing properties of piracetam, a weak learning version of this task--whereby chic ...
Corticosterone, injected embryonically into eggs hatched in the dark, improved retention for a weak passive avoidance task in day-old chicks, the optimal time points for injection were days E19 to E20, resembling those found previously for light exposure, ...
Cell adhesion molecules (CAMs) of the immunoglobulin superfamily, NCAM and L1, as well as the post-translational addition of alpha-2, 8-linked polysialic acid (PSA) homopolymers to NCAM (PSA-NCAM), have been implicated in the neural mechanisms underlying m ...
Long-term memory formation for a weak passive avoidance task in day-old chicks is facilitated by corticosterone administration. Since (i) glutamatergic systems, through different receptor types, play a key role in learning and memory processes, and (ii) gl ...
Stress-related adrenal steroid hormones modulate brain and cognitive function. Electrophysiological studies, including primed burst potentiation and long-term potentiation, have indicated concentration-dependent inverted U-shape effects of corticosterone i ...
Corticosterone has a biphasic effect on memory formation, short-term effects being facilitating and long-term effects resulting in cognitive impairments. The effects of different patterns of temporal exposure to corticosterone-previously shown to biphasica ...
