Programmable Multistable Mechanisms for Safe Surgical Puncturing

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Capacitive sensor to monitor the level of drug inside an injector pen

Sylvain Paul Fernand Joly

Diabete is a disease which is spreading faster than ever, impacting now a larger population. Patients suffering from this disease need the injection of insulin to control extracellular sugar levels. Pharmaceutical companies developed injector pens to allow ...

EPFL2021

Automated Analysis of Cerebrospinal Fluid Flow and Motile Cilia Properties in The Central Canal of Zebrafish Embryos

François Gallaire, Ludovic Pierre Gustave Keiser

Circulation of cerebrospinal fluid (CSF) plays an important role during development. In zebrafish embryo, the flow of CSF has been found to be bidirectional in the central canal of the spinal cord. In order to compare conditions and genetic mutants across ...

BIO-PROTOCOL2021

A new Euler-Lagrangian cavitation model for tip-vortex cavitation with the effect of non-condensable gas

Mohamed Farhat, Huaiyu Cheng

Numerical simulation of tip vortex cavitation (TVC) remains a challenging task in a variety of applica-tions, such as axial turbines and pumps as well as marine propellers. Although it is well known that TVC is highly sensitive to gas content, be it dissol ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Bistable Puncturing Tool for Retinal Vein Cannulation

Yves Bellouard, Simon Nessim Henein, Charles Baur, Lisa Anaïs Jeanne Bonnefoy

An innovative surgical tool prototype dedicated to safe puncturing has been developed for the treatment of retinal vein occlusions (RVOs). The tool is manufactured monolithically by femtolaser printing in fused silica. It consists of a programmable bistabl ...

2020

Facile Fabrication of Microfluidic Chips for 3D Hydrodynamic Focusing and Wet Spinning of Polymeric Fibers

Fabien Sorin, René M. Rossi, Efe Armagan, Claudio Toncelli, Akin Gürsoy

Microfluidic wet spinning has gained increasing interest in recent years as an alternative to conventional wet spinning by offering higher control in fiber morphology and a gateway for the development of multi-material fibers. Conventionally, microfluidic ...

2020

Interaction and breakup of droplet pairs in a microchannel Y-junction

Tobias Schneider, Simon Sebastian Schütz

We combine theory, numerical simulation, and experiments to investigate the breakup of two identical droplets entering a Y-junction with controlled spatial offset by which the second droplet trails the first. Based on fully resolved 3D simulations, we desc ...

AMER PHYSICAL SOC2020

Three-dimensional electrodes for dielectrophoretic applications

Kevin Keim

This thesis reports the use of metal-coated three-dimensional SU-8 electrodes for dielectrophoretic bio sensing and particle manipulation applications. Placing free standing three-dimensional electrodes in microfluidic channels, electric fields can be appl ...

EPFL2020

From bulk descriptions to emergent interfaces: Connecting the Ginzburg-Landau and elastic-line models

Elisabeth Agoritsas, Thierry Giamarchi

Controlling interfaces is highly relevant from a technological point of view. However, their rich and complex behavior makes them very difficult to describe theoretically, and hence to predict. In this work, we establish a procedure to connect two levels o ...

2020

Minimum energy adaptive structures – All-In-One problem formulation

Gennaro Senatore, Yafeng Wang

This paper presents a new All-In-One (AIO) implementation of an existing formulation to design adaptive structures through Total Energy Optimization (TEO). The method implemented in previous work is a nested optimization process, here named TEO-Nested. Num ...

2020

Automated phenotyping of Caenorhabditis elegans embryos with a high-throughput-screening microfluidic platform

Martinus Gijs, Matteo Cornaglia, Raphaël Etienne Jean Trouillon, Hüseyin Baris Atakan, Tunç Alkanat

The nematode Caenorhabditis elegans has been extensively used as a model multicellular organism to study the influence of osmotic stress conditions and the toxicity of chemical compounds on developmental and motility-associated phenotypes. However, the sev ...

2020

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