Protein Folding: Mechanisms and Consequences

This lecture delves into the intricate process of protein folding, exploring the consequences of misfolding and aggregation. The instructor explains how misfolded proteins expose hydrophobic residues, leading to aggregation and posing risks to cellular health. The role of chaperones in assisting protein folding and preventing aggregation is also discussed, shedding light on their ancient origins and mechanisms. Additionally, the lecture covers the energy landscape of protein folding, mutations, and the impact of external factors like temperature. The importance of ATP in the folding process is highlighted, emphasizing its role in providing energy for protein conformation changes.