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This lecture provides a comprehensive overview of flexible guides, mechanical elements that connect rigid mechanical sequences, allowing certain movements while preventing others. It explores the intrinsic properties of various springs, blades, and rods used as guides, discussing their degrees of freedom and applications in mechanical systems. The lecture delves into the analysis of kinematic mechanisms, the concept of hyperstatic structures, and the design principles for achieving desired properties in flexible guides. It also covers technological aspects such as material selection, manufacturing technologies like wire EDM, and the importance of parallel kinematics in complex mechanisms. The lecture concludes by highlighting the significance of flexible guides in micro-technology, emphasizing their precision, lack of friction, and challenges at high speeds and varying temperatures.