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This lecture discusses the journey of genomic medicine from research to clinical application, focusing on national programs in genomic medicine worldwide. It explores the concept of personalized medicine, the challenges of genomic sequencing, and the ethical issues surrounding genomics research. The lecture emphasizes the importance of promoting changes in medical practices and collecting evidence for further implementation. It also delves into the establishment of national initiatives in medicine, with a spotlight on rare diseases and cancer. The lecture concludes by addressing the ethical considerations and implications of genomic research, including the protection of data and the rights of research participants.