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This lecture covers the importance of enzymes as drug targets, focusing on examples such as cyclooxygenases, dihydrofolate reductase, protein kinase C, tyrosine kinases, GABA transaminase, HIV aspartyl protease, and angiotensin-converting enzyme. It explains the development of molecules targeting these enzymes and the specificity of inhibitors. The lecture also discusses the role of tyrosine kinase inhibitors in cancer treatment, with a spotlight on imatinib. Furthermore, it delves into the control of vascular smooth muscle tone, the renin-angiotensin system, and the synthesis of vasoconstrictor Angiotensin II. The session concludes with insights into the viral life cycle, pharmacological interventions, and the development of ritonavir through structure-based drug design.