Immunodominance: Antibody Responses and Vaccine Design

This lecture by the instructor covers the concept of immunodominance in antibody responses and its implications for vaccine design. It delves into the modulation of antibody responses through immunoengineering, focusing on strategies to enhance the immune system's therapeutic potential. The presentation discusses the role of antibodies in identifying and neutralizing foreign objects, the challenges faced in vaccine development due to pathogen evolution, and the use of computational tools for protein design. Furthermore, it explores the design of synthetic immunogens to guide antibody maturation, boost subdominant neutralizing antibodies, and reshape antibody specificities. The lecture concludes with insights on multi-site cocktail vaccines, in vitro evolution of designed immunogens, and the principles for designing effective synthetic immunogens.