TRP Channels: Sensory Perception

This lecture explores the transient receptor potential (TRP) ion channels, focusing on their role in sensory perception of heat, cold, and pain. It covers the structure, activation, and physiological functions of TRP channels, including TRPV1 and TRPM8. The lecture delves into the modulation of TRP channels by various stimuli, such as temperature, chemicals, and membrane potential. Additionally, it discusses the covalent activation of TRPA1 by pungent compounds and the involvement of TRP channels in mechanisms like nociception and cold perception. The presentation also touches on TRP channels' role in mechanosensation, particularly in hearing in Drosophila.