Total Synthesis: Regidins and Ecteinascidin-743

This lecture covers the total synthesis of Regidins and Ecteinascidin-743, detailing a three-step synthesis process with high yields and the deep insight into the structure provided by Ugi 4CR. It also explores Fukuyama's synthesis of Ecteinascidin-743 and the unique structure of (+)-Peganumine A, an octacyclic alkaloid with low uM activity against various cancer cell lines.