Organ-on-Chip: Biomedical Research and Cancer Modeling

This lecture explores the field of Organ-on-Chip, focusing on creating micro-environments to study tissue and organ function, disease progression, and drug development. The instructor, Prof. Jaap den Toonder, explains the philosophy, opportunities, and technologies of Organ-on-Chip, showcasing examples from cancer research. The lecture delves into the importance of Organ-on-Chip in revolutionizing drug development, reducing costs, and improving testing accuracy. It covers the use of induced Pluripotent Stem Cells, microfluidics, and microfabrication in creating advanced multi-cellular culture systems. Additionally, it discusses the modeling of cancer metastasis and the role of ECM stiffness in tumor progression.