This lecture covers the first law of thermodynamics, focusing on the conservation of energy through different transformations. It explains the concept of work (W) and heat (Q) exchanges, emphasizing that their sum is independent of the path taken. The lecture also delves into the energy internal U, which includes macroscopic and microscopic energies. It discusses the exchange of energy at both macroscopic and microscopic levels, highlighting the relationship between work, heat, and the total energy conservation. The presentation concludes with examples of classic transformations and the interconversion of macroscopic and microscopic energies.