This lecture covers the most common defect types in 2D materials, including point defects like vacancies and substitutions, as well as line defects such as grain boundaries and lateral heterostructures. The influence of these defects on field-effect transistor characteristics is discussed, along with strategies to avoid grain boundaries. The lecture also delves into the quantum capacitance of 2D semiconductors and the impact of a dielectric environment on electrical transport. Various methods for defect healing, such as chemical treatments with thiols and TFSI superacid, are explored, highlighting their positive effects on reducing contact resistance and enabling single-photon sources.