Proteinopathy Mapping: Connecting Proteotoxicity to Intrinsic Functions

This lecture by the instructor explores the concept of proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins. It delves into the systems cell biology using alpha-synuclein as a case in point, discussing the relationship between proteotoxicity and intrinsic protein function. The lecture covers topics such as protein synthesis, folding, misfolding, proteostasis machinery, and the impact of mutations and external stresses on protein aggregation. It also examines the role of transport factors, stress response activators, and membrane interactions in protein aggregation. Furthermore, it discusses the pathology of Parkinson's Disease as an archetypal neurodegenerative disease, focusing on alpha-synuclein mutations, multiplication, and polymorphisms.