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This lecture discusses the equilibrium between hemoglobin and oxygen, and how it shifts in the presence of carbon monoxide, leading to serious health issues. The instructor explains the new equilibrium equation, the calculation of the equilibrium constant, and the impact of carbon monoxide on hemoglobin affinity for oxygen. Through numerical applications, the lecture demonstrates the high equilibrium constant when hemoglobin binds carbon monoxide, highlighting the dangers of carbon monoxide poisoning even at low concentrations.