Mannich Reaction: Applications and Mechanism

In course

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Description

This lecture covers the Mannich reaction, focusing on the generation of imines and its application in natural product synthesis, such as Robinson's Three-Component Synthesis of Tropinone. It also discusses the mechanism of the Mannich reaction, including the formation of iminium and Eschenmoser's salt. Furthermore, it explores related reactions like Knoevenagel condensation, Michael addition, and Weiss-Cook condensation. The lecture concludes with the Robinson Annulation, showcasing the combination of Michael addition and intramolecular aldolization.

Instructor

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Official source

https://mediaspace.epfl.ch/media/0_bf71d1n8

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