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This lecture covers the molecular interactions in biomolecules, focusing on nucleic acids. It explains the structure of nucleotides, the pentose sugars in DNA and RNA, and the formation of phosphodiester linkages. The lecture also delves into the bases present in DNA and RNA, the polymerization of nucleotides, and the 3D structure of DNA, including the double helix formation and the different forms it can adopt. Additionally, it discusses the significance of grooves in DNA double helices and the role they play in protein recognition.