Chirality and Asymmetric Synthesis

This lecture covers the importance and determination of chirality, methods for generating enantiopure compounds, and the synthesis of enantio-enriched compounds. It explores the challenge of discodermolide, definitions of chirality, and the significance of stereochemistry in organic synthesis. The course delves into the recognition of key stages in asymmetric multistep syntheses and the elements of stereochemistry in reactions of alkenes and carbonyls. Emphasis is placed on the strategies and methodologies for efficient building block preparation and the synthesis of complex molecules. Various methods for determining enantiomeric excess and the generation of new chirality elements are also discussed.