Nuclear Receptors: Drug Targets

This lecture covers the nuclear receptor family, including examples like mineralocorticoid receptor, glucocorticoid receptor, and peroxisome proliferator-activated receptor. It explains their role in endocrine signaling, metabolic regulation, and drug pharmacology. The lecture delves into the structural organization of nuclear receptors, downstream signaling pathways, and molecular mechanisms of transactivation and transrepression. It also discusses the physiological roles of PPARγ receptors in adipose tissue, glucose homeostasis, and their relevance in diseases like diabetes and cancer. Furthermore, it explores the genetic variability in nuclear receptors affecting drug pharmacokinetics and interactions.