Adipocytes and Leptin Regulation

This lecture covers the evolution and functions of adipocytes, focusing on their role in regulating fat mass, nutrient homeostasis, immune response, and more. It delves into the endocrine functions of fat cells, emphasizing the production of leptin and other hormones. The discussion extends to brown fat and its unique heat-generating properties, as well as the discovery and effects of leptin as an 'adipostat'. The presentation also explores the impact of leptin deficiency on patients and the intricate biology of leptin in various tissues and metabolic processes. Additionally, the lecture addresses ghrelin as a ligand for the growth hormone secretagogue receptor and the multiple factors involved in regulating food intake, including leptin, serotonin, and neuropeptide Y.