Protein Structure: General Principles

This lecture covers the hierarchical organization of protein structures, from primary to quaternary structures, protein domains, and motifs. It explains how protein folding is driven by the hydrophobic core formation and the role of backbone conformations. The importance of sequence in determining protein structure and folding is highlighted, along with the Anfinsen Experiment's insights. Key concepts such as the Ramachandran diagram, backbone torsion angles, and the hydrophobic effect are discussed, emphasizing the diverse three-dimensional structures proteins can adopt.