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This lecture introduces a new approach for fast, deep, and large area detection using multispot multiphoton microscopy, which allows for high spatial detail, high acquisition speed, and a large field of view. The optical scheme for multispot illumination, multi raster scanning, and multi-photon confocal line scanning microscopy are discussed, along with the advantages of this technique. The presentation also covers the application of this approach in the Human Brain Project and the collaboration with the Patrick and Lina Drahi Foundation.