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This lecture introduces the concepts of statistical physics, focusing on isolated systems and the relationship between entropy and disorder. The instructor discusses the statistical mechanics of gases, calorimetric coefficients, and the Boltzmann distribution. The lecture explores the calculation of configurations in grand canonical ensembles and the application of Boltzmann's formula. Key topics include the statistical description of systems, the normalization coefficient, and the Gibbs free energy. The lecture emphasizes the importance of understanding the relationship between energy, entropy, and the number of configurations in a system.