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This lecture provides a detailed observation of the histology of the human spleen, focusing on the structure of the capsule, the composition of red and white pulp, and the unique sinusoidal vessels. The instructor explains the presence of trabeculae, the role of white pulp in immune response, and the identification of fibrous structures within the spleen. Emphasis is placed on recognizing sinusoids and understanding the distinct characteristics of reticular fibers. The lecture concludes with a reminder that the microscopic anatomy of the spleen will be revisited in a future course, offering guidance on further studies and encouraging students to reach out for assistance.