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This lecture covers the structure and functions of intermediate filaments, which provide mechanical resistance and perform various functions in cells. Topics include the composition of filaments, their role in stiffening the nuclear envelope, and their connection to sites of cell contact. The lecture also discusses the stretchability and durability of intermediate filaments, comparing their assembly to a rope. Additionally, the presentation explores the differences between intermediate filaments, actin, and tubulin proteins, emphasizing the dynamic and adaptable nature of the cytoskeleton. The role of intermediate filaments in providing mechanical resistance to the skin is highlighted, along with a brief overview of the cytoskeleton in bacteria.