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This lecture explores the fundamental group of symmetries in quantum mechanical rotations, discussing the SU(2) and SO(3) groups, infinitesimal transformations, group representations, and the topology of S2 and S3. The instructor explains the concept of simply connected groups, the relationship between SU2 and SO3, and the importance of understanding the double connectedness of S3. The lecture delves into the topological properties of rotation groups, the significance of projective representations, and the distinction between SO3 and SU2 in quantum mechanics.