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This lecture covers the dissociation curve of hemoglobin in the lungs and tissues, the toxic role of CO in competing with O2 on hemoglobin, CO2 transport in the blood, the Haldane effect of O2 on CO2 saturation, ventilation regulation loops, O2 and CO2 chemical receptors, pH and CO2 role in respiration regulation, O2 level role in respiration regulation, hypoxic stimulus, hypoxia effect on exercise respiration response, EPO role in hypoxia control, blood pH regulation, effects of ventilation on blood pH, effects of blood pH on ventilation, role of chemical buffers and respiration on blood pH, effects of respiratory and metabolic disorders on pH.