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This lecture covers the dissociation curve of hemoglobin in the lungs and tissues, the toxic role of CO in competing with O2 binding to hemoglobin, CO2 transport in the blood, the Haldane effect of O2 on CO2 saturation, ventilation regulation loops, O2 and CO2 chemical receptors, pH and CO2 role in respiration regulation, O2 level role in respiration regulation, hypoxic stimulus, hypoxia effect on exercise respiration response, EPO role in hypoxia control, blood pH regulation, effects of ventilation and chemical buffers on blood pH, and the impact of respiratory and metabolic disorders on pH.