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This lecture covers the requirements of materials for tissue engineering, including challenges, stem cells, and organoids. It delves into the course content, materials overview, interactions, and specific applications. The instructor discusses the use of cells, engineering, and materials methods to improve or replace biological tissues, focusing on scaffolds, natural or synthetic. The lecture also explores the role of biomaterials in controlling stem-cell fate and tissue regeneration, emphasizing the design principles for successful application in stem-cell biology. Various techniques such as self-assembly, decellularization, and 3D printing for tissue engineering are highlighted, along with the importance of balancing self-renewal and differentiation in stem cells.